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Plot 33 Janet Duniya St, Apo, Abuja, Nigeria

Ovulation Induction

Preimplantation Genetic Testing (PGT): Ensuring Healthier Embryos Before Pregnancy

Introduction

Preimplantation Genetic Testing (PGT) is an advanced reproductive technology used during In Vitro Fertilization (IVF) to evaluate embryos for genetic or chromosomal abnormalities before they are transferred into the uterus. This powerful tool helps improve pregnancy success rates, reduce the risk of miscarriage, and prevent the transmission of inherited disorders.

At Viva Fertility Clinic, we offer state‑of‑the‑art PGT services to help individuals and couples make informed decisions and increase their chances of having a healthy baby.

What Is Preimplantation Genetic Testing?

PGT involves analyzing a few cells from an embryo (usually on Day 5 or 6 at the blastocyst stage) to assess its genetic health. Only embryos that are chromosomally normal or free from specific genetic diseases are selected for transfer.

PGT is categorized into three main types:

1️⃣ PGT‑A (Preimplantation Genetic Testing for Aneuploidy)

Screens embryos for abnormal chromosome numbers (e.g., Down syndrome, Turner syndrome). Purpose: Improve implantation rates and reduce miscarriage.

2️⃣ PGT‑M (Preimplantation Genetic Testing for Monogenic Disorders)

Detects single‑gene disorders such as:

  • Sickle cell disease

  • Cystic fibrosis

  • Thalassemia

  • BRCA mutations Purpose: Prevent transmission of inherited diseases.

3️⃣ PGT‑SR (Preimplantation Genetic Testing for Structural Rearrangements)

Identifies chromosomal structural abnormalities such as translocations or inversions. Purpose: Reduce the risk of implantation failure or recurrent miscarriage.

Who Should Consider PGT?

PGT is recommended for:

  • Women aged 35 and above

  • Couples with recurrent pregnancy loss

  • Individuals with a family history of genetic disorders

  • Couples with previous failed IVF cycles

  • Men or women with chromosomal abnormalities

  • Carriers of single‑gene disorders

  • Same‑sex couples or individuals using donor gametes who want additional reassurance

 

How PGT Works: Step‑by‑Step

1️⃣ IVF and Embryo Development

Eggs and sperm are combined in the laboratory to create embryos.

2️⃣ Embryo Biopsy

A few cells are gently removed from the embryo at the blastocyst stage. The embryo remains unharmed and is frozen while testing is performed.

3️⃣ Genetic Analysis

The biopsied cells are examined using advanced genetic technologies such as:

  • Next‑generation sequencing (NGS)

  • Polymerase chain reaction (PCR)

  • Microarray analysis

4️⃣ Embryo Selection

Only genetically normal or disease‑free embryos are selected for transfer.

5️⃣ Embryo Transfer

A healthy embryo is transferred into the uterus during a future cycle.

Benefits of Preimplantation Genetic Testing

  • Higher IVF success rates

  • Reduced risk of miscarriage

  • Lower chance of genetic disease transmission

  • Improved embryo selection

  • Fewer failed IVF cycles

  • Greater confidence and peace of mind

Limitations and Considerations

While PGT is highly advanced, it has some considerations:

  • It does not guarantee pregnancy.

  • It cannot detect all genetic conditions.

  • Embryo biopsy requires specialized expertise.

  • Some embryos may not survive to the biopsy stage.

  • Ethical and emotional factors may influence decision‑making.

At Viva Fertility Clinic, we provide thorough counselling to help patients understand the benefits and limitations before proceeding.

Preimplantation Genetic Testing is a transformative tool in modern fertility care. By identifying healthy embryos before pregnancy, PGT increases the chances of a successful outcome and helps families avoid the burden of inherited genetic conditions.

At Viva Fertility Clinic, we combine cutting‑edge technology with compassionate care to help you build the healthiest family possible.

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Plot 33 Janet Duniya Street, Apo 900104, Abuja, Nigeria

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